Mairi Manzil

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Human Genome Sequencing

human-genome-sequencing-project
Human Genome Sequencing is rapidly growing these days in 2020s, but in general Genome Sequencing is not something new, it has been there for many years but  The first Human Genome project start in 1990 where USD 2.6 billion were invested and project completed in 2003 and it costed USD 10 million to sequence 1 Genome. Today, Big Data and Computing Power has complimented Genome Sequencing it is costing USD 1,400 or less and genome is sequenced within few days. 


DNA is the Code of Life

Our DNA has all the encrypted information about us and our ancestors DNA is in fact THE CODE OF LIFE , in form four basis of chemicals adenine (A), guanine (G), cytosine (C), and thymine (T).  The combination of these basis are similar to Binary codes in Computers, you must have seen popular ladder like structure of DNA, where 3 billion combination of these codes when sequenced gives us information about our body. This is called GENOME Sequencing.


Why we need Genome Sequencing?

SMBG You must have used  Self-Monitoring Blood Glucose (SMBG) which tell you about the sugar level so that you can take medicines accordingly. These kind of devices have been there fore many years. Old method that existed before these digital devices were strips which were de-oxidized and then it's color was compared to a color chart to see the Sugar level, these devices were used up to 1980s and then later replaced with SMBG and today we can see CGM Devices (Continues Glucose Monitoring) that is monitoring Sugar level continuously and updates the cloud with data on real-time so that physicians can see it on real time. But is the only information we need about our body. We also need to get better diagnosis in fact predictive diagnoses and Genome Sequencing can help this. In fact, it has answer to many questions but let us first see why this has become so important topic these days in 2020s.

Computing Technology an enabler for Genome Sequencing;


Industrial revolution inventions has changed the world, where Augmented Intelligence, Machine learning, Block-chain,  Big data and 5 G   are key drivers for the 4th Industrial Revolution. Which is enabler for many fields of life , that is the reason genome sequencing earned most of its coverage in Popular Science recently. Earlier as mentioned above regarding the first project of genome sequencing it took years to sequence one genome but due to Computing Power, Storage Space specially big data technology has helped Genome Sequencing where high performance computing servers were working day and night to sequence the DNA now it can be done in minutes using the computing power. Sequencing of DNA codes if processed in computer is so huge that previous technology couldn't handle it but now in 2020, technology has improved enough that some hidden information in our DNA can be encrypted and processed.


What is Genome and Sequencing?


Genome is a term for DNA and as you know we have 37 trillion cells in our body, these cells have nucleus and nucleus has chromosomes and chromosomes have DNA. Our DNA has all the encrypted information about us and our ancestors DNA is in fact THE CODE OF LIFE , in form four basis of chemicals adenine (A), guanine (G), cytosine (C), and thymine (T).  The combination of these basis are similar to Binary codes in Computers, you must have seen popular ladder like structure of DNA, where 3 billion combination of these codes when sequenced gives us information about our body. This is called GENOME Sequencing.


Who is doing it today?


Illumina, Inc. is an American company incorporated that develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. They have installed the equipment in more than 11,000 hospitals, research labs and medical facilities where 7 million consumer samples were collected in 2017.

Why Genome sequencing is done?

Today Genome sequencing can help us to know age, face, skin color, height, weight etc.  But it is set to revolutionize the diagnosis, early diagnosis, better health, personalized and precise medication.  Prediction will help us to act better and live a better life. 


Developing Countries and Human Genome Project.

Where developed countries have done enough research and have many resources. Developing countries have human resource , specially India, who  have good number of software developers, India has Launched their first human cataloging genome project in October,  2019.


Future of Genome Sequencing

We have heard about personalized medicines buzz words. If you have seen the personalize Inhaler which asthma patients are using, it tells them on real time about external environment. Similarly, NASA has a handheld Genome Sequencing device which Astronomers are using in Space to record their DNA sequencing which later tells the Biomedical Scientists if there was any change in DNA in space. As phenotype has definitely and effect on genotype. 

The pace at which technology is growing rapidly, there is no doubt Self-Monitoring Blood Glucose (SMBG) will be replaced with Genome Diagnosis Device which will read the code of our life on real time and  will tell us everything about us.

Above post is my research from various resources and last paragraph is my personal view.
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